Prevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State

Authors

  • Ahmadu Shehu Mohammed Nigerian Navy Reference Hospital, Ojo Lagos
  • Odekunle Bola Odegbemi Nigerian Navy Hospital Warri https://orcid.org/0000-0002-5429-9429
  • Chinedu Igwe Naval Medical Centre, Naval Dockyard Limited, Victoria Island, Lagos
  • Nurudeen AA Hussain Ministry of Defence Health Implementation Programme, Abuja
  • Biobelu Abaye Bayelsa State Ministry of Health, Yenagoa
  • Usman Oladipo Adekanye Ministry of Defence Health Implementation Programme, Abuja

DOI:

https://doi.org/10.31646/gbio.110

Keywords:

Dengue fever, Febrile, Military, Immunoglobulins

Abstract

Background: Dengue fever, (df) is a mosquito-borne disease caused by the dengue virus. Infection with dengue virus is a major cause of morbidity in the tropical and sub-tropical parts of the world. In about 60% of cases, it gives rise to undifferentiated fever which is clinically indistinguishable from other viral infections. Dengue fever is known to occur in Nigeria, but the magnitude of this disease remains unclear. This study was done to determine the prevalence and determinants of df immunoglobulins (Ig) among patients attending a military hospital in Lagos.


Methods: Systematic random sampling was used to recruit participants. Study participants were patients presenting with febrile illness at Naval Medical Centre, Victoria Island, Lagos. A semi-structured, interviewer-administered questionnaire was used to collect data and 3 millilitres venous blood was drawn from each participant. Anti-dengue IgM and IgG was determined from whole blood using lateral flow chromatographic immunoassay in line with manufacturer’s instructions. Thick blood film was used for malaria microscopy. Epi-info version 7.2 was employed for data analysis using descriptive statistics and bivariate analysis at 5% level of significance.


Results:  Mean age of study participants was 30.1 ± 13.6 years and 182 (59.9%) were males. The prevalence of df IgM and IgG was 8.5% and 18.0% respectively. Malaria-dengue fever co-infection was 10.8%. Individuals with malaria were twice less likely to have df (OR: 0.46, 95%CI: 0.27 - 0.78). Military personnel and their relations were about 3 times less likely to have df (OR: 0.35, 95%CI: 0.18 - 0.66). Joint pain was significantly associated with df (OR: 1.78, 95%CI: 1.05 - 2.99).


Conclusions: A significant proportion of study population had both df IgM and IgG. Screening for df should be part of routine tests amongst patients that presents with febrile illness particularly those with joint pain.

Author Biographies

Ahmadu Shehu Mohammed, Nigerian Navy Reference Hospital, Ojo Lagos

Consultant Public Health Physician

Odekunle Bola Odegbemi, Nigerian Navy Hospital Warri

Odekunle is a young graduate of the Nigeria Field Epidemiology and Laboratory Training Programme. He holds n MPH in Laboratory Epidemiology Practice from the prestigious premier University of Ibadan and a MSc. in Clinical Chemistry from University of Benin. He is a Nigerian Naval Officer and and a Medical Laboratory Scientist. He is presently the Officer in Charge, Medical Laboratory Department at the Nigerian Navy Hospital Warri; where he's responsible for producing quality diagnostic results for disease diagnosis, monitoring and treatment of ailments. As a Field Epidemiologist and member, AFENET Corp of Disease Detectives, Odekunle has responded to over seven major disease outbreaks and participated in three National Public Health Surveys. He has 9 published papers in reputed journals including part publications in local and international conference proceedings. Odekunle has passion for infectious diseases and forensic science.

Chinedu Igwe, Naval Medical Centre, Naval Dockyard Limited, Victoria Island, Lagos

Optometrist and Epidemiologist

Nurudeen AA Hussain, Ministry of Defence Health Implementation Programme, Abuja

Consultant Public Health Physician

Biobelu Abaye, Bayelsa State Ministry of Health, Yenagoa

Field Epidemiologist

Usman Oladipo Adekanye, Ministry of Defence Health Implementation Programme, Abuja

Clinical Research

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Published

2021-10-05

How to Cite

Mohammed, A. S., Odegbemi, O. B., Igwe, C., Hussain, N. A., Abaye, B., & Adekanye, U. O. (2021). Prevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State. Global Biosecurity, 3(1). https://doi.org/10.31646/gbio.110

Issue

Vol. 3 (2021)

Section

Research Articles

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Received 2021-04-20
Accepted 2021-09-16
Published 2021-10-05